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According to Aronne, the treatment of obesity has undergone a remarkable transformation in recent years, with drugs like semaglutide and tirzepatide leading the charge

Chronic kidney disease: GLP-1 receptor agonists have shown renoprotective effects in clinical trials (FLOW trial with semaglutide), and orforglipron could be evaluated for similar indications

Elokda, A

While subcutaneous injections provide 100% systemic bioavailability, oral mucosal delivery utilizes highly vascularized tissue under the tongue to absorb the peptides directly into the bloodstream

These findings highlight the therapeutic potential of targeting lipid metabolism pathways in the prevention and management of liver diseases, including HCC, through natural compounds